Fixed-dose combination therapy in hypertension: cons

F Angeli, G Reboldi, G Mazzotta, M Garofoli… - High Blood Pressure & …, 2012 - Springer
The goal of antihypertensive therapy is to reduce the risk associated with blood pressure
elevation. Although the choice of first-line drug therapy may exert some effects on different …

Fixed and low-dose combinations of blood pressure-lowering agents: for the many or the few?

M Leggio, A Fusco, C Loreti, G Limongelli, MG Bendini… - Drugs, 2019 - Springer
Despite the widespread availability of several effective classes of drugs, systemic arterial
hypertension remains poorly controlled in the majority of patients worldwide. In this article …

Issues in blood pressure control and the potential role of single‐pill combination therapies

M Burnier, RE Brown, SH Ong… - … journal of clinical …, 2009 - Wiley Online Library
Hypertension (HTN) is a major risk factor for cardiovascular mortality, yet only a small
proportion of hypertensive individuals receive appropriate therapy and achieve target blood …

More medications, fewer pills: combination medications for the treatment of hypertension

R Lewanczuk, SW Tobe - Canadian journal of cardiology, 2007 - Elsevier
Achieving blood pressure targets in hypertension can be challenging. Often, patients require
multiple medications to reach these targets. The Canadian Hypertension Education Program …

Improving blood pressure control rates by optimizing combination antihypertensive therapy

BJ Epstein - Expert opinion on pharmacotherapy, 2010 - Taylor & Francis
Importance of the field: Hypertension is the most common preventable cause of
cardiovascular morbidity and mortality. Despite the availability of a multitude of …

Combination drug treatment of hypertension: have we come full circle?

AA Taylor - Current Cardiology Reports, 2004 - Springer
Only 30% of hypertensive patients achieved and maintained adequate blood pressure
control on a single drug in recent clinical trials. For the majority of patients who require two …

Creating a combination antihypertensive regimen: what does the research show?

MA Weber - The Journal of Clinical Hypertension, 2003 - Wiley Online Library
Major randomized clinical trials have demonstrated unquestionable clinical benefits of
lowering blood pressure without establishing superiority of any specific antihypertensive …

New approach to blood pressure control: triple combination pill

M Volpe, G Gallo, G Tocci - Trends in Cardiovascular Medicine, 2020 - Elsevier
Blood pressure (BP) control remains insufficient worldwide, mostly due to poor adherence to
treatments, clinical inertia, adverse effects and underuse of drug-combination strategies …

Use of single-pill combination therapy in the evolving paradigm of hypertension management

DA Calhoun - Expert Opinion on Pharmacotherapy, 2009 - Taylor & Francis
The use of antihypertensive therapy is an evolving paradigm. Although blood pressure (BP)
control rates remain low, there have been improvements that may be attributable in part to a …

Using fixed-dose combination therapies to achieve blood pressure goals

SG Chrysant - Clinical drug investigation, 2008 - Springer
Hypertension affects an estimated 88 million Americans and is controlled to the
recommended blood pressure (BP) goal of< 140/90 mmHg in only 37% of individuals with …