Dimethylbisphenol A inhibits the differentiation of stem Leydig cells in adult male rats by androgen receptor (NR3C4) antagonism

L Shi, J Li, F Tian, Y Tang, S Wang, Q Li, Y Zhu, Q Zhu… - Toxicology Letters, 2022 - Elsevier
Dimethylbisphenol A (DMBPA) is a novel alternative to bisphenol A. Whether short-term
exposure to DMBPA affects Leydig cell regeneration remains unknown. The Leydig cell …

Bisphenol S stimulates Leydig cell proliferation but inhibits differentiation in pubertal male rats through multiple mechanisms

P Pan, Z Wen, F Ma, Z Lei, C Pan, Q Fei… - Environmental …, 2023 - Wiley Online Library
Bisphenol S (BPS) is a novel bisphenol A (BPA) analogue, a ubiquitous environmental
pollutant that disrupts male reproductive system. Whether BPS affects Leydig cell maturation …

Bisphenol A stimulates differentiation of rat stem Leydig cells in vivo and in vitro

L Chen, Y Zhao, L Li, L Xie, X Chen, J Liu, X Li… - Molecular and cellular …, 2018 - Elsevier
Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor
linked with sexual precocity. However, its action and underlying mechanisms on male …

[HTML][HTML] Exposure to 4-nonylphenol compromises Leydig cell development in pubertal male mice

S Tao, Z Yao, H Li, Y Wang, X Qiao, Y Yu, Y Li… - Ecotoxicology and …, 2023 - Elsevier
Abstract Exposure to 4-nonyl phenol (4-NP) on Leydig cell (LC) development and function
remains poorly understood. We explored the effects of 4-NP on LC development and …

Bisphenol F blocks Leydig cell maturation and steroidogenesis in pubertal male rats through suppressing androgen receptor signaling and activating G-protein …

H Li, J Li, L Shi, Y Zhu, F Tian, M Shi, Q Li… - Food and Chemical …, 2022 - Elsevier
Bisphenol F (BPF) is a new analog of bisphenol A (BPA). BPA has deleterious effects on the
male reproductive system, but the effect of BPF has not been studied in detail. In this study …

The industrial chemical bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat Leydig cells

MK Nanjappa, L Simon, BT Akingbemi - Biology of reproduction, 2012 - academic.oup.com
The presence of bisphenol A (BPA) in consumer products has raised concerns about
potential adverse effects on reproductive health. Testicular Leydig cells are the predominant …

Bisphenol A attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling

C Li, L Zhang, T Ma, L Gao, L Yang, M Wu, Z Pang… - Chemosphere, 2021 - Elsevier
Bisphenol A (BPA) is an endocrine-disrupting compound that impairs testosterone synthesis
in male mammals. A circadian clock gene deficiency leads to diminished fertility and even …

[HTML][HTML] Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro

J Zhang, G Hu, B Huang, D Zhuo, Y Xu, H Li… - BMC Pharmacology and …, 2019 - Springer
Background It is an established fact that excess of glucocorticoids could cause the harmful
effects, such as suppression on the male reproduction. Although glucocorticoids …

Fluornen-9-bisphenol increases Leydig cell proliferation but inhibits maturation in pubertal male rats via interacting with androgen receptor as an antagonist and …

F Meng, X Li, J Li, Y Zhu, M Su, B Zhang… - Chemico-Biological …, 2022 - Elsevier
Abstract Fluornen-9-bisphenol (BPFL) is used as one of the alternatives for bisphenol A.
However, whether BPFL has deleterious effects to the male reproductive system and the …

Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure

X Li, F Meng, L Ye, X Qiao, J Li, L Tian… - Environmental …, 2022 - Wiley Online Library
Tetramethyl bisphenol A (TMBPA) is a widely used flame retardant. TMBPA has been a toxic
to Leydig cells in puberty, but it remains unclear whether TMBPA has a similar inhibitor effect …