[HTML][HTML] Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

The G-protein-coupled estrogen receptor GPER in health and disease

ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2011 - nature.com
Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

[HTML][HTML] Therapeutic perspectives on the modulation of G-protein coupled estrogen receptor, GPER, function

M Rouhimoghadam, AS Lu, AK Salem… - Frontiers in …, 2020 - frontiersin.org
Estrogens exert their physiological and pathophysiological effects via cellular receptors,
named ERα, ERβ, and G-protein coupled estrogen receptor (GPER). Estrogen-regulated …

Estrogen receptor alpha and beta in health and disease

M Jia, K Dahlman-Wright, JÅ Gustafsson - Best practice & research Clinical …, 2015 - Elsevier
Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in
the regulation of many complex physiological processes in humans. Abnormal ER signaling …

What have we learned about GPER function in physiology and disease from knockout mice?

ER Prossnitz, HJ Hathaway - The Journal of steroid biochemistry and …, 2015 - Elsevier
Abstract Estrogens, predominantly 17β-estradiol, exert diverse effects throughout the body in
both normal and pathophysiology, during development and in reproductive, metabolic …

The many faces of estrogen signaling

P Vrtačnik, B Ostanek, S Mencej-Bedrač, J Marc - Biochemia medica, 2014 - hrcak.srce.hr
Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …

The G protein-coupled oestrogen receptor GPER in health and disease: An update

ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2023 - nature.com
Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology

EJ Filardo, P Thomas - Endocrinology, 2012 - academic.oup.com
Using cDNA cloning strategies commonly employed for G protein-coupled receptors
(GPCR), GPCR-30 (GPR30), was isolated from mammalian cells before knowledge of its …

An overview on Estrogen receptors signaling and its ligands in breast cancer

MZI Khan, M Uzair, A Nazli, JZ Chen - European Journal of Medicinal …, 2022 - Elsevier
Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications

JB Arterburn, ER Prossnitz - Annual Review of Pharmacology …, 2023 - annualreviews.org
The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …