The estrogen receptors, ERα, ERβ, and GPER, mediate the effects of estrogenic compounds
on their target tissues. Estrogen receptors are located in the tissues of the female …

Estrogens are sex hormones that are central to health and disease in both genders. These
hormones have long been recognized to act in complex ways, both through relatively slow …

Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ.
Transcriptional regulation by ERs is controlled by a complex array of factors such as ER …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

The hormone estrogen is involved in both female and male reproduction, as well as
numerous other biological systems including the neuroendocrine, vascular, skeletal, and …

Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …

Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17
million people die worldwide from CVD per year. There is considerable evidence suggesting …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

GPER possesses structural and functional characteristics shared by members of the G-
protein-coupled receptor (GPCR) superfamily, the largest class of plasma membrane …

Estrogens play a crucial role in the regulation of physiological and pathophysiological
processes. These hormones act through specific receptors, most notably the canonical …