Background The treatment of falciparum malaria poses unique challenges in settings where
malaria transmission intensity is high because recurrent infections are common. These …

Background Severe malaria is a medical emergency associated with high mortality.
Adequate treatment requires initial parenteral therapy for fast parasite clearance followed by …

Objective To compare the effectiveness of oral quinine with that of artemether-lumefantrine
in treating uncomplicated malaria in children. Design Randomised, open label effectiveness …

Background. Artemisinin-based combination therapies are now widely recommended as first-
line treatment for uncomplicated malaria. However, which therapies are optimal is a matter …

Background Combination antimalarial therapy is recommended for the treatment of
uncomplicated falciparum malaria in Africa; however, some concerns about the safety and …

The safety and efficacy of the two most widely used fixed-dose artemisinin-based
combination therapies (ACT), artesunate-amodiaquine (ASAQ) and artemether-lumefantrine …

ContextCombination therapy is now widely advocated as first-line treatment for
uncomplicated malaria in Africa. However, it is not clear which treatment regimens are …

Background Artemether-lumefantrine (AL) was adopted as first-line treatment for
uncomplicated malaria in Kenya in 2006. Monitoring drug efficacy at regular intervals is …

Objectives To compare the efficacy and safety of artemisinin combination therapies for the
treatment of uncomplicated falciparum malaria in Uganda. Design Randomized single-blind …

Abstract Background Artesunate-amodiaquine (AS+ AQ) and artemether-lumefantrine (AM-
L) are efficacious artemisinin combination therapy (ACT) regimens that have been widely …