Hyaluronan fragments act as an endogenous danger signal by engaging TLR2
KA Scheibner, MA Lutz, S Boodoo… - The Journal of …, 2006 - journals.aai.org
Upon tissue injury, high mw hyaluronan (HA), a ubiquitously distributed extracellular matrix
component, is broken down into lower mw (LMW) fragments, which in turn activate an innate …
component, is broken down into lower mw (LMW) fragments, which in turn activate an innate …
Hyaluronan as an immune regulator in human diseases
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+ CD25+ regulatory T …
PL Bollyky, BA Falk, RP Wu, JH Buckner… - Journal of leukocyte …, 2009 - academic.oup.com
The authors describe the immunoregulatory contributions of intact versus fragmented
hyaluronan, a prominent component of the extracellular matrix. The composition of the ECM …
hyaluronan, a prominent component of the extracellular matrix. The composition of the ECM …
Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS
Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with
CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters …
CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters …
[HTML][HTML] Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2
KR Taylor, K Yamasaki, KA Radek, A Di Nardo… - Journal of Biological …, 2007 - ASBMB
Inflammation under sterile conditions is not well understood despite its importance in trauma
and autoimmune disease. To investigate this process we established mouse models of …
and autoimmune disease. To investigate this process we established mouse models of …
[HTML][HTML] Immobilized heavy chain-hyaluronic acid polarizes lipopolysaccharide-activated macrophages toward M2 phenotype
H He, S Zhang, S Tighe, J Son, SCG Tseng - Journal of Biological …, 2013 - ASBMB
Despite the known anti-inflammatory effect of amniotic membrane, its action mechanism
remains largely unknown. HC-HA complex (HC-HA) purified from human amniotic …
remains largely unknown. HC-HA complex (HC-HA) purified from human amniotic …
Hyaluronan in tissue injury and repair
A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
[HTML][HTML] Hyaluronan fragments stimulate endothelial recognition of injury through TLR4
KR Taylor, JM Trowbridge, JA Rudisill… - Journal of Biological …, 2004 - ASBMB
Tissues must quickly recognize injury to respond to the rapid pace of microbial growth. In
skin, dermal microvascular endothelial cells must also react to danger signals from the …
skin, dermal microvascular endothelial cells must also react to danger signals from the …
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
C Termeer, F Benedix, J Sleeman, C Fieber… - The Journal of …, 2002 - rupress.org
Low molecular weight fragmentation products of the polysaccharide of Hyaluronic acid
(sHA) produced during inflammation have been shown to be potent activators of …
(sHA) produced during inflammation have been shown to be potent activators of …
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Mechanisms that regulate inflammation and repair after acute lung injury are incompletely
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …