De Novo Design of Functional Coassembling Organic–Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization

BO Okesola, AK Mendoza-Martinez, G Cidonio… - ACS …, 2021 - ACS Publications
Synthetic nanostructured materials incorporating both organic and inorganic components
offer a unique, powerful, and versatile class of materials for widespread applications due to …

Multicomponent hydrogels for the formation of vascularized bone-like constructs in vitro

B Derkus, BO Okesola, DW Barrett, M D'Este… - Acta biomaterialia, 2020 - Elsevier
The native extracellular matrix (ECM) is a complex gel-like system with a broad range of
structural features and biomolecular signals. Hydrogel platforms that can recapitulate the …

3-Dimensional cell-laden nano-hydroxyapatite/protein hydrogels for bone regeneration applications

M Sadat-Shojai, MT Khorasani, A Jamshidi - Materials Science and …, 2015 - Elsevier
The ability to encapsulate cells in three-dimensional (3D) protein-based hydrogels is
potentially of benefit for tissue engineering and regenerative medicine. However, as a result …

Guest‐molecule‐directed assembly of mesostructured nanocomposite polymer/organoclay hydrogels

JE Martin, AJ Patil, MF Butler… - Advanced Functional …, 2011 - Wiley Online Library
Given the urgent need for soft materials with high functional value, hydrogels based on the
integrative assembly of organic polymers and nanoscale inorganic building blocks—so …

Bioinspired mineral hydrogels as nanocomposite scaffolds for the promotion of osteogenic marker expression and the induction of bone regeneration in osteoporosis

Y Zhao, Z Li, Y Jiang, H Liu, Y Feng, Z Wang, H Liu… - Acta Biomaterialia, 2020 - Elsevier
Osteoporosis is one of the most prevalent age-related diseases worldwide and is
characterized by a systemic deterioration of bone strength (bone mineral density and bone …

In Situ Biomimetic Mineralization of Bone-Like Hydroxyapatite in Hydrogel for the Acceleration of Bone Regeneration

K Liang, C Zhao, C Song, L Zhao, P Qiu… - … Applied Materials & …, 2022 - ACS Publications
A critical-sized bone defect, which cannot be repaired through self-healing, is a major
challenge in clinical therapeutics. The combination of biomimetic hydrogels and nano …

Tough nanocomposite double network hydrogels reinforced with clay nanorods through covalent bonding and reversible chain adsorption

G Gao, G Du, Y Cheng, J Fu - Journal of Materials Chemistry B, 2014 - pubs.rsc.org
Polymer hydrogels with superior strength and toughness are potential candidate materials
for the replacement or engineering of load-bearing tissues. This manuscript reports novel …

Multifunctional nanoengineered hydrogels consisting of black phosphorus nanosheets upregulate bone formation

Z Wang, J Zhao, W Tang, L Hu, X Chen, Y Su, C Zou… - Small, 2019 - Wiley Online Library
Tissue‐engineered hydrogels have received extensive attention as their mechanical
properties, chemical compositions, and biological signals can be dynamically modified for …

Growth‐factor free multicomponent nanocomposite hydrogels that stimulate bone formation

BO Okesola, S Ni, B Derkus… - Advanced Functional …, 2020 - Wiley Online Library
Synthetic osteo‐promoting materials that are able to stimulate and accelerate bone
formation without the addition of exogenous cells or growth factors represent a major …

In situ bone regeneration enabled by a biodegradable hybrid double-network hydrogel

Y Zhang, M Chen, J Tian, P Gu, H Cao, X Fan… - Biomaterials …, 2019 - pubs.rsc.org
Stem cell therapy based on advanced biomaterials provides a promising strategy in bone
tissue engineering. Nevertheless, guided bone regeneration which fulfills the criteria in …