Stressors trigger physiological and behavioral responses that are aimed at reinstating
homeostasis, help us cope with the challenges posed by exogenous and endogenous …

Chronic stress is one of the most relevant triggering factors for major depression. Microglial
cells are highly sensitive to stress and, more generally, to environmental challenges …

Microglia, resident immune cells of the CNS are sensitive to various perturbations of the
environment, such as stress exposure, and may be involved in translating these changes to …

Neural circuits are constantly monitored and supported by the surrounding microglial cells,
using finely tuned mechanisms which include both direct contact and release of soluble …

In this e-Book, we collected recent evidence on the role of cytokines (including chemokines)
in the interplay between environmental stimulation and central responses in both …

We recently demonstrated that microglia undergo dynamic alterations in activation state
during the development of chronic unpredictable stress (CUS)-induced depressive-like …

The potential contribution of inflammation to the development of neuropsychiatric diseases
has recently received substantial attention. In the brain, the main immune cells are the …

Recent findings have implicated inflammatory responses in the central nervous system in a
variety of neuropsychiatric and neurodegenerative diseases, and the understanding and …

The potential contribution of inflammation to the development of neuropsychiatric diseases
has recently received substantial attention. In the brain, the main immune cells are the …

Clinical studies suggest that key genetic factors involved in stress resilience are related to
the innate immune system. In the brain, this system includes microglia cells, which play a …