AIM: Therefore this project is aimed at investigating whether the activation of microglia can
be linked to the disturbances in CX3CL1-CX3CR1 system and if the administration of …

In the CNS, the chemokine CX3CL1 (fractalkine) is expressed on neurons while its specific
receptor CX3CR1 is expressed on microglia and macrophages. Microglia play an important …

CX3CR1 is a G protein‐coupled receptor that is expressed exclusively by microglia within
the brain parenchyma. The only known physiological CX3CR1 ligand is the chemokine …

The relationship between the central nervous system (CNS) and microglia is lifelong.
Microglia originate in the embryonic yolk sac during development and populate the CNS …

The hypothalamo-hypophyseal-adrenal axis is activated in different ways in response to
different stressors. A dual regulation of ACTH release was suggested by Fortier 35 years …

Impaired immunoregulation with aging predisposes the elderly to cognitive and
neurobehavioral deficits. The complex communication between the peripheral and …

Several lines of evidence indicate that adverse experience in early life may be a triggering
factor for pathological inflammatory processes and lead to the development of depression …

Glutamate (Glu) is the main excitatory amino acid in the brain and plays a pivotal role in
many neurophysiological functions. Nevertheless, an excess and prolonged exposure to Glu …

Glial cells and neuroinflammation serve key roles, being relevant players in the
pathophysiology of neuronal dysfunction and neurodegeneration. Little is known about the …