Periods of caloric deficit substantially attenuate many centrally mediated responses to acute
stress, including neural drive to the hypothalamic-pituitary-adrenal (HPA) axis, anxiety-like …

The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to
neuron–glia interaction and the regulation of microglial cell activation. Fractalkine is …

Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …

Several neurodegenerative disorders are associated with evidence of inflammation, one
feature of which is increased activation of microglia, the most likely cellular source of …

Neurons producing melanocortin receptor agonist, α-MSH derived from
proopiomelanocortin, and antagonist, agouti-related protein, are known to be sensitive to …

The stress system orchestrates brain and body responses to the environment. Cortisol (in
humans) or corticosterone (in rodents) are important mediators of the stress system. Their …

Background Interactions between fractalkine (CX 3 CL1) and fractalkine receptor (CX 3
CR1) regulate microglial activation in the CNS. Recent findings indicate that age-associated …

Hypothalamic AgRP/NPY neurons are key players in the control of feeding behaviour.
Ghrelin, a major orexigenic hormone, activates AgRP/NPY neurons to stimulate food intake …

Anorexia Nervosa (AN) is viewed as primarily a psychiatric disorder owing to the
considerable behavioral and genetic overlap with mood disorders and other psychiatric …