Simple Summary In spontaneous tumor regression, tumors shrink and disappear without
conventional treatments. This phenomenon challenges the view that cancer is an …

Background Altered cell metabolism is regarded as a hallmark of cancer with numerous
studies highlighting glucose and glutamine as critical nutrients for tumor proliferation …

The present perspective article proposes that cachexia, muscle wasting in cancer, is
mediated by dysregulated phosphate metabolism and phosphate toxicity that can damage …

In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …

Phosphorus, often in the form of inorganic phosphate (Pi), is critical to cellular function on
many levels; it is required as an integral component of kinase signaling, in the formation and …

Background: Cancer therapeutics have a low success rate in clinical trials. An
interdisciplinary approach is needed to translate basic, clinical, and remote fields of …

Tumor epidemiology, as well as tumor microenvironments and cancer cell signaling study,
has been presented with statistical relevance of inorganic phosphate (Pi) to tumorigenesis …

Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are
characterized by a high metabolic plasticity resulting from mutations and the selection of …

Inorganic phosphate (Pi) is required by all living organisms for the development of organs
such as bone, muscle, brain, and lungs, regulating the expression of several critical genes …

Energy metabolism is significantly reprogrammed in many human cancers, and these
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …