Inorganic phosphate (Pi) is a vital component of nucleotides, membrane phospholipids, and
phosphorylated intermediates in cellular signalling. The Growth Rate Hypothesis (GRH) …

Next to smoking, obesity is the second leading preventable risk factor for cancer, but
increasing rates of obesity and overweight are estimated to overtake smoking as the leading …

Inorganic phosphate (Pi) is an essential nutrient to living organisms. It is required as a
component of the energy metabolism, kinase/phosphatase signaling and in the formation …

Recent surveys indicate that Pi intake has increased steadily as Pi-containing foods have
increased. Our previous study demonstrated that high dietary Pi strongly stimulated lung …

Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters
such as oxygen (p O2), extracellular acidosis (pHe), and concentration of interstitial …

Aggressive cancers exhibit an efficient conversion of high amounts of glucose to lactate
accompanied by acid secretion, a phenomenon popularly known as the Warburg effect. The …

Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst
maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost …

Phosphorus is a pivotal element in all biochemical systems: it serves to store metabolic
energy as ATP, it forms the backbone of genetic material such as RNA and DNA, and it …

Cancer cells possess fundamentally altered metabolism that supports their pathogenic
features, which includes a heightened reliance on aerobic glycolysis to provide precursors …

Metabolic reprogramming is required for tumors to meet the bioenergetic and biosynthetic
demands of malignant progression. Numerous studies have established a causal …