Significance: In the last years, metabolic reprogramming, fluctuations in bioenergetic fuels,
and modulation of oxidative stress became new key hallmarks of tumor development. In …

Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable
isotope labeling of amino acids in cell culture coupled with quantitative, label-free …

Efforts to identify new therapeutic targets in cancer primarily focused on oncogenes and
tumor suppressor genes, and their mechanisms of action. However, there is an emerging …

Nutrients are indispensable resources that provide the macromolecular building blocks and
energy requirements for sustaining cell growth and survival. Cancer cells require several …

The present article proposes that the association of inflammation with cancer is potentially
mediated by the interaction of inflammatory hyperemia and hyperphosphatemia. Hyperemia …

Extravasation and metastatic progression are two main reasons for the high mortality rate
associated with cancer. The metastatic potential of cancer cells depends on a plethora of …

Precision oncology is the practice of matching one therapy to one specific patient, based on
particular genetic tumor alterations, in order to achieve the best clinical response. Despite …

Cancer cell metabolism changes are considered a crucial hallmark in the development of
cancer. Cancer cells undergoing uncontrolled proliferation need to rewire their metabolism …

Understanding how cancer cells survive harsh environmental conditions may be
fundamental to eradicating malignancies proven to be impervious to treatment. Nutrient and …

During cancer progression, cancer cells are repeatedly exposed to metabolic stress
conditions in a resource-limited environment which they must escape. Increasing evidence …