Considerable metabolic reprogramming has been observed in a conserved manner across
multiple cancer types, but their true causes remain elusive. We present an analysis of …

A cell committed to proliferation must reshape its metabolism to enable robust yet balanced
production of building blocks for the assembly of proteins, lipids, nucleic acids, and other …

The altered metabolism of cancer can render cells dependent on the availability of metabolic
substrates for viability. Investigating the signaling mechanisms underlying cell death in cells …

Fluctuations in oxygen tension during tissue remodeling impose a major metabolic
challenge in human tumors. Stem-like tumor cells in glioblastoma, the most common …

Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of
malignant behaviors. It supports the proliferation and metastasis of tumor cells according to …

The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in
living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher …

Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, to their
intracellular alkaline pH (pH i). This effect is part of the metabolic alterations found in most, if …

Cancer cells remodel their metabolic network to adapt to variable nutrient availability.
Pentose phosphate pathway (PPP) plays protective and biosynthetic roles by oxidizing …

Inorganic phosphate (Pi) is an essential nutrient to living organisms. It plays a key role in
diverse biological processes, including osteoblast differentiation and skeletal mineralization …

Nutrient limitation results in an activation of autophagy in organisms ranging from yeast,
nematodes and flies to mammals. Several evolutionary conserved nutrient-sensing kinases …