Biological stoichiometry is the study of the balance of energy and multiple chemical
elements in biological systems. A key idea in biological stoichiometry is the growth rate …

Dysregulated metabolism contributes to central characteristics of cancer cells such as
sustained proliferation, resistance toward cell death, and epigenetic alterations (1). At the …

The tumor microenvironment is a complex mix of cancerous and noncancerous cells
(especially immune cells and fibroblasts) with distinct metabolisms. These cells interact with …

Cancer is fundamentally a disease of uncontrolled cell proliferation. Tumour metabolism has
emerged as an exciting new discipline studying how cancer cells obtain the necessary …

Otto Warburg is generally credited to be the ''father''of cancer metabolism for his seminal
discovery of how cancer cells predominantly generate energy through glycolysis rather than …

Cancer remains a leading cause of death in the world today. Despite decades of research to
identify novel therapeutic approaches, durable regressions of metastatic disease are still …

Increased nutrient uptake and usage is a hallmark of many human malignancies. During the
course of tumorigenesis, cancer cells often outstrip their local nutrient supply leading to …

Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming
in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic …

Introduction The pentose phosphate pathway (PPP) branches from glycolysis and is crucial
for cell growth, since it provides necessary compounds for anabolic reactions, nucleotide …

Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble
Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo …