Although kinases have hijacked the scene for several decades now in the battle against
cancer, evidence has accumulated that phosphatases play equally important roles, by …

1. Pascual G, Domínguez D, Elosúa-Bayes M, et al. Dietary palmitic acid promotes a
prometastatic memory via Schwann cells. Nature. 2021; 599: 485–490. 2. Wei Q, Qian Y, Yu …

Phosphatases of regenerating liver are key regulators of met... : Current Opinion in Clinical
Nutrition & Metabolic Care Phosphatases of regenerating liver are key regulators of metabolism …

Cells coordinate their behaviors with the mechanical properties of the extracellular matrix
(ECM). Tumor cells frequently harbor an enhanced nucleotide synthesis, presumably to …

Purpose The hypoxic microenvironment of glioblastoma multiforme (GBM) is thought to
increase resistance to cancer therapies. Recent evidence suggests that hypoxia induces …

Methods: BMG-1 cells were treated with 2, 4-dinitrophenol (DNP) in-vitro, to establish the
OXPHOS-modified (OPM-BMG) cells. Further cellular metabolic characterization was carried …

Abstract TCF1 high progenitor CD8+ T cells mediate the efficacy of PD-1 blockade, however
the mechanisms that govern their generation and maintenance are poorly understood. Here …

Bobko et al. reported a very interesting article concerning the impact of interstitial inorganic
phosphate (Pi) on tumor progression. Previous studies have shown that blood levels of Pi …

Cancer cells must adapt their metabolism to meet the energetic and biosynthetic demands
that accompany rapid growth of the primary tumor and colonization of distinct metastatic …

Abstract pH gradient reversal refers to intracellular alkalization and extracellular acidification
commonly seen in malignant tumors. To meet their high anabolic demand, cancer cells …