Carboxypeptidase E (CPE) has recently been described as a multifunctional protein that
regulates proliferation, migration and survival in several tumor entities. In glioblastoma …

Background A growing tumor in the body can be considered a complex ecological and
evolutionary system. A new eco-evolutionary hypothesis (the “Growth Rate Hypothesis” …

Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical
for cell growth. Hypoxia in tumors represents a hostile environment that can encourage …

Cancer cells need to regulate their metabolic program to fuel several activities, including
unlimited proliferation, resistance to cell death, invasion and metastasis. The aim of this work …

Tumors override energy stress to grow. However, how nucleotide synthesis is regulated
under energy stress is unclear. We demonstrate here that glucose deprivation or hypoxia …

Phosphatase of regenerating liver (PRL) is a family of protein tyrosine phosphatases (PTPs)
that are anchored to the plasma membrane by prenylation. They are frequently …

The interplay between rewiring tumor metabolism and oncogenic driver mutations is only
beginning to be appreciated. Metabolic deregulation has been described for decades as a …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Nutrient stress accompanies several stages of tumor progression, including metastasis
formation. Metabolic reprogramming is a hallmark of cancer, and it has been associated with …

Recent results suggest a paradigm shift from viewing inorganic phosphate as a passive
requirement for basic cell functions to an active regulator of cell behavior. We have …