Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple,
successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in …

The antagonistic interaction with host restriction proteins is a major driver of evolutionary
change for viruses. We previously reported that polymorphisms of the TRIM5α B30. 2/SPRY …

The cytoplasmic TRIM5α proteins of certain mammalian lineages efficiently recognize the
incoming capsids of particular retroviruses and potently restrict infection in a species-specific …

Primate lentiviruses have narrow host ranges, due in part to their sensitivities to mammalian
intracellular antiviral factors such as APOBEC3G and TRIM5α. Despite the protection …

It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can
affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can …

There is considerable variability in host susceptibility to human immunodeficiency virus type
1 (HIV-1) infection, but the host genetic determinants of that variability are not well …

Recent studies showed that nonhuman primate TRIM5α can efficiently block HIV-1 infection
in human cell lines. It can also restrict other retroviruses, therefore, suggested as a general …

ABSTRACT TRIM5α is a potent barrier to cross-species retroviral transmission, and
TRIM5αs from different species have divergent antiretroviral specificities. Multiple TRIM5 …

Primate genomes encode a variety of innate immune strategies to defend themselves
against retroviruses. One of these, TRIM5α, can restrict diverse retroviruses in a species …

Human immunodeficiency virus type 1 (HIV-1) efficiently enters cells of Old World monkeys
but encounters a block before reverse transcription. This restriction is mediated by a …