An Evolutionary Screen Highlights Canonical and Noncanonical Candidate Antiviral Genes within the Primate TRIM Gene Family
R Malfavon-Borja, SL Sawyer, LI Wu… - Genome biology and …, 2013 - academic.oup.com
Recurrent viral pressure has acted on host-encoded antiviral genes during primate and
mammalian evolution. This selective pressure has resulted in dramatic episodes of …
mammalian evolution. This selective pressure has resulted in dramatic episodes of …
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5α
RM Newman, L Hall, M Connole… - Proceedings of the …, 2006 - National Acad Sciences
Retroviral restriction factor TRIM5α exhibits a high degree of sequence variation among
primate species. It has been proposed that this diversity is the cumulative result of ancient …
primate species. It has been proposed that this diversity is the cumulative result of ancient …
Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5α
T Hatziioannou, D Perez-Caballero… - Proceedings of the …, 2004 - National Acad Sciences
Mammalian cells express several factors that act in a cell-autonomous manner to inhibit
retrovirus replication. Among these are the Friend virus susceptibility factor 1/lentivirus …
retrovirus replication. Among these are the Friend virus susceptibility factor 1/lentivirus …
[HTML][HTML] Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity
LMJ Ylinen, AJ Price, J Rasaiyaah, S Hué… - PLoS …, 2010 - journals.plos.org
TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old
World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of …
World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of …
Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5α
EM Campbell, O Perez, JL Anderson… - The Journal of cell …, 2008 - rupress.org
TRIM5 proteins constitute a class of restriction factors that prevent host cell infection by
retroviruses from different species. TRIM5α restricts retroviral infection early after viral entry …
retroviruses from different species. TRIM5α restricts retroviral infection early after viral entry …
TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling
MG Grütter, J Luban - Current opinion in virology, 2012 - Elsevier
TRIM5 is a restriction factor that blocks retrovirus infection soon after the virion core enters
the cell cytoplasm. Restriction activity is targeted to the virion core via recognition of the …
the cell cytoplasm. Restriction activity is targeted to the virion core via recognition of the …
Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5α (TRIM5α) by heterologous TRIM domains
Tripartite motif 5α (TRIM5α) restricts some retroviruses, including human immunodeficiency
virus type 1 (HIV-1), from infecting the cells of particular species. TRIM5α is a member of the …
virus type 1 (HIV-1), from infecting the cells of particular species. TRIM5α is a member of the …