Inhibition of interleukin-17A, but not interleukin-17F, signaling lowers blood pressure, and reduces end-organ inflammation in angiotensin II–induced hypertension
Inflammatory cytokines play a major role in the pathophysiology of hypertension. The
authors previously showed that genetic deletion of interleukin (IL)-17A results in blunted …
authors previously showed that genetic deletion of interleukin (IL)-17A results in blunted …
Role of interleukin-23/interleukin-17 axis in T-cell-mediated actions in hypertension
Current knowledge suggests that hypertension is in part mediated by immune mechanisms.
Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive …
Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive …
Interleukin 17A: key player in the pathogenesis of hypertension and a potential therapeutic target
GK Davis, DJ Fehrenbach, MS Madhur - Current hypertension reports, 2021 - Springer
Abstract Purpose of Review To summarize key advances in our understanding of the role of
interleukin 17A (IL-17A) in the pathogenesis of hypertension and highlight important areas …
interleukin 17A (IL-17A) in the pathogenesis of hypertension and highlight important areas …
Interleukin 17A participates in renal inflammation associated to experimental and human hypertension
M Orejudo, RR Rodrigues-Diez… - Frontiers in …, 2019 - frontiersin.org
Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …
Interleukin 17 promotes angiotensin II–induced hypertension and vascular dysfunction
We have shown previously that T cells are required for the full development of angiotensin II–
induced hypertension. However, the specific subsets of T cells that are important in this …
induced hypertension. However, the specific subsets of T cells that are important in this …
Interleukin-17A regulates renal sodium transporters and renal injury in angiotensin II–induced hypertension
Angiotensin II–induced hypertension is associated with an increase in T-cell production of
interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted …
interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted …
Interleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension
H Nguyen, VL Chiasson, P Chatterjee… - Cardiovascular …, 2013 - academic.oup.com
Aims Elevated levels of pro-inflammatory cytokine interleukin-17A (IL-17) are associated
with hypertensive autoimmune diseases; however, the connection between IL-17 and …
with hypertensive autoimmune diseases; however, the connection between IL-17 and …
Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation
M Orejudo, AB García-Redondo… - Clinical …, 2020 - portlandpress.com
An important link exists between hypertension and inflammation. Hypertensive patients
present elevated circulating levels of proinflammatory cytokines, including interleukin-17A …
present elevated circulating levels of proinflammatory cytokines, including interleukin-17A …
Low-dose IL-17 therapy prevents and reverses diabetic nephropathy, metabolic syndrome, and associated organ fibrosis
R Mohamed, C Jayakumar, F Chen… - Journal of the …, 2016 - journals.lww.com
Diabetes is the leading cause of kidney failure, accounting for> 45% of new cases of
dialysis. Diabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress …
dialysis. Diabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress …
IL-18 (Interleukin-18) produced by renal tubular epithelial cells promotes renal inflammation and injury during deoxycorticosterone/salt-induced hypertension in mice
IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood
pressure and end-organ damage is unknown. We examined the role of IL-18 in the …
pressure and end-organ damage is unknown. We examined the role of IL-18 in the …
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