Inflammatory cytokines play a major role in the pathophysiology of hypertension. The
authors previously showed that genetic deletion of interleukin (IL)-17A results in blunted …

Current knowledge suggests that hypertension is in part mediated by immune mechanisms.
Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive …

Abstract Purpose of Review To summarize key advances in our understanding of the role of
interleukin 17A (IL-17A) in the pathogenesis of hypertension and highlight important areas …

Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …

We have shown previously that T cells are required for the full development of angiotensin II–
induced hypertension. However, the specific subsets of T cells that are important in this …

Aims Elevated levels of pro-inflammatory cytokine interleukin-17A (IL-17) are associated
with hypertensive autoimmune diseases; however, the connection between IL-17 and …

Angiotensin II–induced hypertension is associated with an increase in T-cell production of
interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted …

An important link exists between hypertension and inflammation. Hypertensive patients
present elevated circulating levels of proinflammatory cytokines, including interleukin-17A …

Diabetes is the leading cause of kidney failure, accounting for> 45% of new cases of
dialysis. Diabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress …

IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood
pressure and end-organ damage is unknown. We examined the role of IL-18 in the …