The autoantigen in Goodpasture disease is the noncollagenous domain of α3 type IV
collagen [α3 (IV) NC1]. We previously demonstrated that IL-12p40−/− mice are protected …

Chronic inflammation in arterial wall that is driven by immune cells and cytokines plays
pivotal roles in the development of atherosclerosis. Interleukin 27 (IL-27) is a member of the …

Interleukin 23 receptor expressing IL‐17 producing T cells have been shown to be important
in the development of murine lupus. The usefulness of IL‐23 inhibition in ameliorating lupus …

Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas lpr mice with renal
injury. Phagocyte-derived interleukin-12 (IL-12) is a key cytokine that induces the …

IL-22 is an epithelial cell survival cytokine that is currently under development for the
treatment of acute liver damage. Here, we used a mouse model of renal …

Abstract Purpose of Review Low-grade inflammation drives elevations in blood pressure
(BP) and consequent target organ damage in diverse experimental models of hypertension …

Chronic inflammatory diseases like psoriasis, Crohn's disease (CD), multiple sclerosis (MS),
rheumatoid arthritis (RA), and others are increasingly recognized as disease entities, where …