[HTML][HTML] Non-alcoholic fatty liver disease, and the underlying altered fatty acid metabolism, reveals brain hypoperfusion and contributes to the cognitive decline in APP …
A Pinçon, O De Montgolfier, N Akkoyunlu, C Daneault… - Metabolites, 2019 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease, is
associated with cognitive decline in middle-aged adults, but the mechanisms underlying this …
associated with cognitive decline in middle-aged adults, but the mechanisms underlying this …
[HTML][HTML] Non-alcoholic fatty liver disease induces signs of Alzheimer's disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model
DG Kim, A Krenz, LE Toussaint, KJ Maurer… - Journal of …, 2016 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease afflicting
about one third of the world's population and 30% of the US population. It is induced by …
about one third of the world's population and 30% of the US population. It is induced by …
[PDF][PDF] High‐Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease
CR Bosoi, M Vandal, M Tournissac… - Hepatology …, 2021 - Wiley Online Library
Obesity and diabetes are strongly associated not only with fatty liver but also cognitive
dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor for …
dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor for …
Emerging links between nonalcoholic fatty liver disease and neurodegeneration
TJ Kelty, RJ Dashek, WD Arnold… - Seminars in Liver …, 2023 - thieme-connect.com
The association between liver and brain health has gained attention as biomarkers of liver
function have been revealed to predict neurodegeneration. The liver is a central regulator in …
function have been revealed to predict neurodegeneration. The liver is a central regulator in …
[HTML][HTML] Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice
D Jansen, V Zerbi, IAC Arnoldussen, M Wiesmann… - PloS one, 2013 - journals.plos.org
Recent studies have focused on the use of multi-nutrient dietary interventions in search of
alternatives for the treatment and prevention of Alzheimer's disease (AD). In this study we …
alternatives for the treatment and prevention of Alzheimer's disease (AD). In this study we …
[HTML][HTML] Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation
SY Cheon, J Song - Cell & Bioscience, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple
pathologies. The progression of dementia with NAFLD may be affected by various risk …
pathologies. The progression of dementia with NAFLD may be affected by various risk …
Effects of short‐term Western diet on cerebral oxidative stress and diabetes related factors in APP× PS1 knock‐in mice
CM Studzinski, F Li, AJ Bruce‐Keller… - Journal of …, 2009 - Wiley Online Library
A chronic high fat Western diet (WD) promotes a variety of morbidity factors although
experimental evidence for short‐term WD mediating brain dysfunction remains to be …
experimental evidence for short‐term WD mediating brain dysfunction remains to be …
Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer's …
Background Neuroinflammation is a recognized hallmark of Alzheimer's disease, along with
accumulation of amyloid-β plaques, neurofibrillary tangles and synaptic loss. n-3 …
accumulation of amyloid-β plaques, neurofibrillary tangles and synaptic loss. n-3 …
[HTML][HTML] Metabolic defects caused by high-fat diet modify disease risk through inflammatory and amyloidogenic pathways in a mouse model of Alzheimer's disease
High-fat diet (HFD) has been shown to accelerate Alzheimer's disease (AD) pathology, but
the exact molecular and cellular mechanisms remain incompletely understood. Moreover, it …
the exact molecular and cellular mechanisms remain incompletely understood. Moreover, it …
Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral deficits in a mice model of Alzheimer's disease
K Wu, X Gao, B Shi, S Chen, X Zhou, Z Li, Y Gan, L Cui… - Neuroscience, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accompanied by
memory deficits and neuropsychiatric dysfunction. Omega-3 polyunsaturated fatty acids (n-3 …
memory deficits and neuropsychiatric dysfunction. Omega-3 polyunsaturated fatty acids (n-3 …