[HTML][HTML] Molecular mechanisms of metformin for diabetes and cancer treatment
M Li, X Li, H Zhang, Y Lu - Frontiers in physiology, 2018 - frontiersin.org
Metformin has been the first-line drug treatment for hyperglycemia and insulin resistance for
over 50 years. However, the molecular basis of its therapeutic role remained incompletely …
over 50 years. However, the molecular basis of its therapeutic role remained incompletely …
Metformin as an anticancer agent
A Vancura, P Bu, M Bhagwat, J Zeng… - Trends in pharmacological …, 2018 - cell.com
Metformin has been a frontline therapy for type 2 diabetes (T2D) for many years. Its
effectiveness in T2D treatment is mostly attributed to its suppression of hepatic …
effectiveness in T2D treatment is mostly attributed to its suppression of hepatic …
Metformin: Insights into its anticancer potential with special reference to AMPK dependent and independent pathways
Metformin has been known for its antidiabetic effects for decades and is used as a first line
therapy in type 2 diabetes. But recently its anticancer potential has also been discovered …
therapy in type 2 diabetes. But recently its anticancer potential has also been discovered …
[HTML][HTML] Metformin, cancer and glucose metabolism
Metformin is the first-line treatment for type 2 diabetes. Results from several clinical studies
have indicated that type 2 diabetic patients treated with metformin might have a lower cancer …
have indicated that type 2 diabetic patients treated with metformin might have a lower cancer …
Metformin and cancer: between the bioenergetic disturbances and the antifolate activity
JA Jara, R Lopez-Munoz - Pharmacological research, 2015 - Elsevier
For decades, metformin has been the first-line drug for the treatment of type II diabetes
mellitus, and it thus is the most widely prescribed antihyperglycemic drug. Retrospective …
mellitus, and it thus is the most widely prescribed antihyperglycemic drug. Retrospective …
[HTML][HTML] Metformin and cancer, an ambiguanidous relationship
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …
[HTML][HTML] Metformin antagonizes cancer cell proliferation by suppressing mitochondrial-dependent biosynthesis
Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest
as an antineoplastic agent. Recent work suggests that metformin directly antagonizes …
as an antineoplastic agent. Recent work suggests that metformin directly antagonizes …
[HTML][HTML] Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
A Luengo, LB Sullivan, MGV Heiden - BMC biology, 2014 - Springer
Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the
most widely prescribed antidiabetic drug. Retrospective studies have found that metformin …
most widely prescribed antidiabetic drug. Retrospective studies have found that metformin …
Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells
Metformin, a first line medication for type II diabetes, initially entered the spotlight as a
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …
Metformin: a novel but controversial drug in cancer prevention and treatment
X Sui, Y Xu, X Wang, W Han, H Pan… - Molecular …, 2015 - ACS Publications
Metformin, a biguanide derivative that is widely used for treating type 2 diabetes mellitus,
has recently been shown to exert potential anticancer effects. Many retrospective data and …
has recently been shown to exert potential anticancer effects. Many retrospective data and …