BACKGROUND Prostate cancer linkage studies have been used to localize rare and
presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity …

BACKGROUND Although the subject of intensive study, the genetic influences responsible
for familial clustering of prostate cancer remain largely unidentified. Genome‐wide scans for …

Prostate cancer is one of the most common cancers among men and has long been
recognized to occur in familial clusters. Brothers and sons of affected men have a twofold to …

Results from over a dozen prostate cancer susceptibility genome-wide scans,
encompassing some 1,500 hereditary prostate cancer families, indicate that prostate cancer …

Prostate cancer is the most common malignancy diagnosed in men in the US. Genetic
susceptibility to prostate cancer has been well documented. A region at chromosome 20q13 …

Background: Prostate cancer represents a substantial public health burden worldwide. It is
the second leading cause of cancer death among men in the United States. A family history …

Evidence of the existence of major prostate cancer (PC)–susceptibility genes has been
provided by multiple segregation analyses. Although genomewide screens have been …

Epidemiological and twin studies have consistently demonstrated a strong genetic
component to prostate cancer (PCa) susceptibility. To date, numerous linkage studies have …

Prostate cancer linkage studies have suggested the existence of a prostate cancer
susceptibility gene on chromosome 17q21–22. We now report the results of an extended …

BACKGROUND There is strong evidence for genetic susceptibility to prostate cancer, but
most of the genes underlying this susceptibility remain to be identified. METHODS We …