Frequent sequence variants of human glycine N-acyltransferase (GLYAT) and inborn errors of metabolism
D Schulke, JO Sass - Biochimie, 2021 - Elsevier
Glycine conjugation is an important phase II reaction and represents a central detoxification
pathway which is essential for the recycling of free coenzyme A. Only few sequence variants …
pathway which is essential for the recycling of free coenzyme A. Only few sequence variants …
Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase
R Van der Sluis, CPS Badenhorst… - Gene, 2013 - Elsevier
Human glycine N-acyltransferase (human GLYAT) detoxifies a wide range of endogenous
and xenobiotic metabolites, including benzoate and salicylate. Significant inter-individual …
and xenobiotic metabolites, including benzoate and salicylate. Significant inter-individual …
Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway
R Van der Sluis, CPS Badenhorst, E Erasmus… - Gene, 2015 - Elsevier
Thorough investigation of the glycine conjugation pathway has been neglected. No defect of
the glycine conjugation pathway has been reported and this could reflect the essential role …
the glycine conjugation pathway has been reported and this could reflect the essential role …
Genetic polymorphisms of glycine N-acyltransferase (GLYAT) in a French Caucasian population
CL Lino Cardenas, J Bourgine, C Cauffiez, D Allorge… - Xenobiotica, 2010 - Taylor & Francis
In humans, the glycine N-acyltransferase enzyme (GLYAT) is thought to be important in the
detoxification of endogenous and xenobiotic compounds which contain a carboxylic acid …
detoxification of endogenous and xenobiotic compounds which contain a carboxylic acid …
Enzymatic characterization and elucidation of the catalytic mechanism of a recombinant bovine glycine N-acyltransferase
CPS Badenhorst, M Jooste, AA Van Dijk - Drug Metabolism and Disposition, 2012 - ASPET
Glycine conjugation, a phase II detoxification process, is catalyzed by glycine N-
acyltransferase (GLYAT; EC 2.3. 1.13). GLYAT detoxifies various xenobiotics, such as …
acyltransferase (GLYAT; EC 2.3. 1.13). GLYAT detoxifies various xenobiotics, such as …
Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl–CoA
JM Rohwer, C Schutte, R van der Sluis - International Journal of …, 2021 - mdpi.com
The glycine conjugation pathway in humans is involved in the metabolism of natural
substrates and the detoxification of xenobiotics. The interactions between the various …
substrates and the detoxification of xenobiotics. The interactions between the various …
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
CPS Badenhorst, R van der Sluis… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-
acyltransferase (GLYAT, EC 2.3. 1.13), is an important metabolic pathway responsible for …
acyltransferase (GLYAT, EC 2.3. 1.13), is an important metabolic pathway responsible for …
New insights into the catalytic mechanism of human glycine N‐acyltransferase
Even though the glycine conjugation pathway was one of the first metabolic pathways to be
discovered, this pathway remains very poorly characterized. The bi‐substrate kinetic …
discovered, this pathway remains very poorly characterized. The bi‐substrate kinetic …
Expression, purification, and characterization of mouse glycine N-acyltransferase in Escherichia coli
DR Dempsey, JD Bond, AM Carpenter… - Protein expression and …, 2014 - Elsevier
Glycine N-acyltransferase (GLYAT) is a phase II metabolic detoxification enzyme for
exogenous (xenobiotic) and endogenous carboxylic acids; consisting of fatty acids, benzoic …
exogenous (xenobiotic) and endogenous carboxylic acids; consisting of fatty acids, benzoic …
Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma
M Matsuo, K Terai, N Kameda, A Matsumoto… - Biochemical and …, 2012 - Elsevier
The human glycine-N-acyltransferase (hGLYAT) gene and two related-genes (GLYATL1
and GLYATL2) were isolated. Human GLYAT, GLYATL1, and GLYATL2 cDNAs were …
and GLYATL2) were isolated. Human GLYAT, GLYATL1, and GLYATL2 cDNAs were …