Rare variation in the TREM2 gene is associated with a broad spectrum of
neurodegenerative disorders including Alzheimer's disease (AD). TREM2 encodes a …

Rare variation in TREM2 has been associated with greater risk for Alzheimer's disease (AD).
TREM2 encodes a cell surface receptor expressed on microglia and related cells, and the …

Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …

Homozygous mutations in exon 2 of TREM2, a gene involved in Nasu-Hakola disease, can
cause frontotemporal dementia (FTD). Moreover, a rare TREM2 exon 2 variant (p. R47H) …

Rare non-synonymous variants of TREM2 have recently been shown to be associated with
Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using a well …

Objective: A rare variant in TREM2 (p. R47H, rs75932628) has been consistently reported to
increase the risk for Alzheimer disease (AD), while mixed evidence has been reported for …

TREM2: a new risk factor for Alzheimers disease Page 1 Clin Genet 2013: 83: 525–529 Printed
in Singapore. All rights reserved © 2013 John Wiley & Sons A/S. Published by Blackwell …

The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor
expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory …

Background: Genetic variants in TREM2 are strongly associated with Alzheimer's disease
(AD) risk but alternative splicing in TREM2 transcripts has not been comprehensively …

Two recent studies have identified that a rare coding variant (p. R47H) in exon 2 of triggering
receptor expressed on myeloid cells 2 (TREM2) gene is associated with Alzheimer's disease …