A central question in development biology is how a limited set of signalling pathways can
instruct unlimited diversity of multicellular organisms. In this review, we use three ocular …

Background: A major step in eye morphogenesis is the transition from optic vesicle to optic
cup, which occurs as a ventral groove forms along the base of the optic vesicle. A ventral …

The fibroblast growth factor (FGF) family is known to be involved in vertebrate eye
development. However, distinct roles of individual FGF members during eye development …

Cell signaling molecules secreted from strategically localized positions coordinate cell
behavior to enable progressive specification of embryonic tissues. These molecules …

Fibroblast growth factors (FGFs) play important roles in many aspects of development,
including lens development. The lens is derived from the surface ectoderm and consists of …

FGF signaling plays a pivotal role in eye development. Previous studies using in vitro chick
models and systemic zebrafish mutants have suggested that FGF signaling is required for …

Fibroblast growth factors (Fgf) are secreted signaling molecules that have mitogenic,
patterning, neurotrophic and angiogenic properties. Their importance during embryonic …

During embryonic development, pattern formation must be tightly synchronized with tissue
morphogenesis to coordinate the establishment of the spatial identities of cells with their …

The vertebrate lens provides an excellent model to study the mechanisms that regulate
terminal differentiation. Although fibroblast growth factors (FGFs) are thought to be important …

Since the days of Hans Spemann, the ocular lens has served as one of the most important
developmental systems for elucidating fundamental processes of induction and …