Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …

Bone marrow mesenchymal stem cells (BMSCs) nowadays are regarded as promising
candidates in cell‐based therapy for the regeneration of damaged bone tissues that are …

Osteoporosis is characterized by systemic microarchitecture impairment and bone loss,
which ultimately lead to fragility fractures. This disease is most common in older people …

Objective To determine genome‐wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …

Mesenchymal stem cells (MSC) are capable of multipotent differentiation into connective
tissues and as such are an attractive source for autologous cell-based regenerative …

Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic
mechanisms including DNA methylation. Methylation changes may also play a key role in …

Age-related bone loss in humans is associated with a decrease in bone formation relative to
bone resorption, although the mechanisms for this impairment in bone formation with aging …

Objective Human synovium–derived mesenchymal stem cells (MSCs) can efficiently
differentiate into mature chondrocytes. It has been suggested that DNA methylation is one …

Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …

Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion
prior to use as cell-based therapies in immunological and tissue repair applications. Aging …