Osteoarthritis (OA) is a common joint disorder with increasing impact in an aging society.
While genetic and transcriptomic analyses have revealed some genes and non-coding loci …

Aging is associated with bone loss and degenerative joint diseases, in which the aging of
bone marrow-derived mesenchymal stem cell (bmMSC) may play an important role. In this …

During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined
osteogenesis accompanied by excess adipogenesis, which will lead to osteoporosis. Here …

Objectives Bone marrow mesenchymal stem cells (BMSCs) hold a high osteogenic
differentiation potential, but the mechanisms that control the osteogenic ability of BMSCs …

Human bone marrow-derived mesenchymal stem cells (hBMSCs) are important for tissue
regeneration but their epigenetic regulation is not well understood. Here we investigate the …

Bone is a major organ in the skeletal system that supports and protects muscles and other
organs, facilitates movement and hematopoiesis, and forms a reservoir of minerals including …

Mesenchymal stem cells (MSCs) can differentiate into multiple mesodermal cell types in
vitro; however, their differentiation capacity is influenced by their tissue of origin. To what …

Epigenetic modifications of cytosine residues in the DNA play a critical role for cellular
differentiation and potentially also for aging. In mesenchymal stromal cells (MSC) from …

Epigenetic mechanisms are known to regulate gene expression during chondrogenesis. In
this study, we have characterized the epigenome during the in vitro differentiation of human …

A variety of osteoarticular conditions possess an underlying genetic aetiology. Large-scale
genome-wide association studies have identified several genetic loci associated with …