The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Reproductive maturation and function are maintained by a complex neurohormonal network
that integrates at the so-called hypothalamic–pituitary–gonadal (HPG) axis. This system is …

Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis,
but the molecular and cellular mechanisms by which hormonal and environmental signals …

Kisspeptins, which are products of the Kiss1 gene, and their receptor, GPR54, have
emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) …

Unraveling of the master role of kisspeptins, the products of the KiSS-1 gene, and their
receptor, GPR54, in the control of reproduction has been a major breakthrough in …

Kisspeptins, a family of neuropeptides encoded by the Kiss1 gene that are mainly expressed
in discrete neuronal populations of the hypothalamus, have recently emerged as essential …

Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …

In humans and other mammals, a hallmark of female reproductive function is the capacity to
episodically release fertilizable oocytes under the precise control of a cascade of hormonal …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …