Development of new anticoagulants has been in constant demand throughout the world due
to increasing rate of morbidity and mortality caused by thrombotic diseases. Factor Xa (FXa) …

Thrombosis is a leading cause of death in cardiovascular diseases such as myocardial
infarction (MI), unstable angina and acute coronary syndrome (ACS) in the industrialized …

Thromboembolic diseases are the leading causes of morbidity and mortality in the
developed world. Anticoagulants provide effective treatment for venous or arterial …

Introduction: Thrombosis is a common causal pathology for stroke, acute coronary syndrome
and venous thromboembolism disorders, which are the leading cause of death worldwide …

Introduction: Factor Xa (FXa) is a critical enzyme in the coagulation cascade responsible for
thrombin generation, the final enzyme that leads to fibrin clot formation. Significant success …

Thrombosis is a major cause of mortality in the industrialized world. Therefore, the control of
blood coagulation has become a major target for new therapeutic agents. One attractive …

As a pathological coagulation process, thrombus can lead to many serious diseases,
including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome …

Importance of the field. New oral anticoagulants with favorable safety profiles and fixed
doses are required for the management of thromboembolism and stroke prevention in …

Factor Xa (fXa) is a key enzyme in the coagulation cascade and an essential component of
the prothrombinase complex, which activates prothrombin to thrombin, leading to fibrin clot …

Factor Xa is a serine protease that has a critical role in the blood coagulation cascade by
ultimately regulating the production of thrombin. There is now ample evidence for the role of …