Herein, we report on the identification of three potent glycine and related amino acid-based
series of FXa inhibitors containing a neutral P1 chlorophenyl pharmacophore. A X-ray …

Parallel synthesis and structure–activity relationships of a series of highly potent, selective,
and neutral factor Xa inhibitors - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Abstract Factor Xa (FXa) is an enzyme belonging to the serine protease family which plays a
vital role in hemostasis, being an essential part in the blood-clotting cascade by catalyzing …

Coronary heart disease (CHD) is the leading cause of mortality and morbidity in the United
States. Currently, there are approximately 12 million Americans with CHD, which is most …

Further optimization of the β-aminoester class of factor Xa (fXa) inhibitors is described
culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with …

We report the design and synthesis of a novel class of N, N′-disubstituted aroylguanidine-
based lactam derivatives as potent and orally active FXa inhibitors. The structure–activity …

Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in blood coagulation
linking the intrinsic and extrinsic pathways to the final common pathway of the coagulation …

A series of cis-1, 2-diaminocyclohexane derivatives were synthesized with the aim of
optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5–6 fused rings …

The limitations of conventional anticoagulants have stimulated the development of new
anticoagulants. The central position of factor Xa (FXa) at the junction of the intrinsic and …