Novel anticoagulants to replace unfractionated heparins, low molecular weight heparins and
vitamin K antagonists, are needed urgently. Coagulation factor Xa is an attractive target for …

Anticoagulant use is recommended for the prevention and treatment of several
thromboembolic disorders including venous thromboembolism. However, anticoagulants …

Factor Xa (fXa) is an important serine protease that holds the central position linking the
intrinsic and extrinsic activation mechanisms in the blood coagulation cascade. Therefore …

Factor Xa (FXa) is a trypsin-like serine protease involved in the coagulation cascade and
has received great interest as a potential target for the development of new antithrombotic …

Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic
pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide …

Design, Synthesis, and SAR of Amino Acid Derivatives as Factor Xa Inhibitors -
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Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral
analysis. Modification of lead compound 7 by transformation of its N-oxide 6–6 biaryl ring …

Inappropriate thrombus formation within blood vessels is the leading cause of mortality in
the industrialized world. Factor Xa (FXa) is a trypsin-like serine protease that plays a key role …

The design, synthesis and SAR of a novel class of valerolactam-based arylsulfonamides as
potent and selective FXa inhibitors is reported. The arylsulfonamide–valerolactam scaffold …

We have been researching orally active factor Xa inhibitor for a long time. We explored the
new diamine linker using effective ligands to obtain a new attractive original scaffold 2 …