The activated serine protease factor Xa is a promising target for new anticoagulants. After
studies on naturally occurring factor Xa inhibitors indicated that such agents could be …

We have been researching orally active factor Xa inhibitor for a long time. We explored the
new diamine linker using effective ligands to obtain a new attractive original scaffold 2 …

Due to its critical role in the coagulation cascade Factor Xa became an important target for
antithrombotic drug development. The design of the first generation of Factor Xa inhibitors …

Oral factor Xa (FXa) inhibitors are a promising alternative to current anticoagulants. This
paper reviews the latest developments of oral direct FXa inhibitors and focuses on those …

Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing
effective and safe anticoagulants. Although a large number of FXa inhibitors have been …

Starting from the achiral and potent factor Xa inhibitor 1, a new and flexible solid-phase
optimisation strategy is described to reduce its cationic character. By replacing one …

Direct inhibition of FXa has emerged as an effective strategy to achieve anticoagulation
maintaining normal hemostasis with minimal bleeding risks. A novel series of …

Factor Xa (fXa) is an important serine protease in the blood coagulation cascade. Inhibition
of fXa has emerged as an attractive target for potential therapeutic applications in the …

Background: Factor Xa (FXa) has been a target of considerable interest for drug
development efforts aimed at suppressing thrombosis. In this report, a new orally active …

We have already reported unique compounds containing a N, O-spiro acetal structure as an
orally active factor Xa (FXa) inhibitor. This time, we described a N, N-spiro acetal structure as …