Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …

Frontotemporal lobar degeneration (FTLD) is a devastating neurodegenerative disease that
is the second most common form of dementia affecting individuals under age 65. The most …

Background The essential role of progranulin (PGRN) as a neurotrophic factor has been
demonstrated by the discovery that haploinsufficiency due to GRN gene mutations causes …

Frontotemporal lobar degeneration (FTLD), a neurodegenerative disease primarily affecting
the frontal and temporal lobes, is one of the most common types of dementia. While the …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …

Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …

Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …