Progranulin deficiency is thought to cause some forms of frontotemporal dementia (FTD), a
major early-onset age-dependent neurodegenerative disease. How progranulin (PGRN) …

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are
overlapping neurodegenerative disorders. Mutations in the growth factor progranulin …

Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal
lobar degeneration with ubiquitin and TAR–DNA binding protein 43-positive inclusions by …

Recent studies suggest progranulin (GRN) is a neurotrophic factor. Loss-of-function
mutations in the progranulin gene (GRN) cause frontotemporal lobar degeneration (FTLD), a …

Progranulin (PGRN) haploinsufficiency resulting from loss-of-function mutations in the
PGRN gene causes frontotemporal lobar degeneration accompanied by TDP-43 …

Background: Progranulin is implicated in frontotemporal dementia (FTD), but its role in other
neurodegenerative disorders is unknown. Objective: To investigate the levels of progranulin …

Background Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal
lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed …

Progranulin (PGRN) is a widely expressed multifunctional protein, involved in regulation of
cell growth and cell cycle progression with a possible involvement in neurodegeneration …

Loss‐of‐function mutations in progranulin (GRN) are associated with frontotemporal lobar
degeneration with intraneuronal ubiquitinated protein accumulations composed primarily of …

Heterozygous mutations in the granulin (GRN) gene, resulting in the haploinsufficiency of
the progranulin (PGRN) protein, is a leading cause of frontotemporal lobar degeneration …