Progranulin (PGRN) haploinsufficiency accounts for up to 10% of frontotemporal lobe
dementia. PGRN has also been implicated in neuroinflammation in acute and chronic …

J. Neurochem.(2010) 112, 1305–1315. Abstract Frontotemporal dementia with ubiquitin‐
positive inclusions (FTLD‐U) can be caused by mutations in the progranulin gene (GRN) …

Background and purpose: Progranulin (PGRN) expression is increased in activated
microglia in Alzheimer's disease (AD) brain, suggesting a potential role in this pathology …

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is characterized by
progressive decline in behavior, executive function, and language. Progranulin (GRN) gene …

The purpose of this brief overview of the progranulin protein is to provide a sense of the
range and extent of the roles of progranulin in normal physiology and pathology …

Background: Pathogenic mutations in the granulin gene (GRN) are causative in 5-10% of
patients with frontotemporal dementia (FTD), mostly leading to reduced progranulin protein …

Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its
function in the central nervous system is unknown. Roles in development, sexual …

Frontotemporal dementia (FTD) is the second most common form of dementia. It affects the
frontal and temporal lobes of the brain and has a highly heterogeneous clinical …

The reduced production or activity of the cysteine-rich glycoprotein progranulin is
responsible for about 20% of cases of familial frontotemporal dementia. However, little is …

Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …