Constitutively activated signal transducer and activator of transcription 3 (STAT3) factor is an
important therapeutic target in head and neck cancer (HNC). Despite early promising …

The surface reactivity of gold nanoparticles (AuNPs) is receiving attention as a
radiosensitizer of cancer cells for radiation therapy and/or as a drug carrier to target cells …

A major problem in the treatment of head and neck cancer today is the resistance of tumors
to traditional radiation therapy, which results in 40% local failure, despite aggressive …

Radiotherapy is the major form of treatment for head and neck carcinoma, a malignant
tumour of epithelial origin. The identification of agents, which can be co‑administered in …

Abstract Ataxia-telangiectasia-mutated (ATM) is a radiosensitization gene. In the present
study, we investigated the efficacy of poly (D, L-lactide-co-glycolide)(PLGA) nanoparticles …

Simple Summary Activated STAT3 is an essential factor in cancer development; therefore,
blocking STAT3 may be of therapeutic benefit in multiple cancer types. Thanks to recent …

The biosynthesis of nanomedicine has gained enormous attention and exhibited promising
prospects, while the underlying mechanism and advantage remain not fully understood …

Background Radiotherapy is a major therapeutic modality for locally advanced head and
neck cancer. However, the effectiveness of radiotherapy is hindered by resistance …

Previous studies showed that gold nanoparticles (AuNPs) are useful radiosensitizers which
optimize radiation therapy under low-dose radiation. However, the mechanisms of AuNP …

Abstract Objectives Gold nanoparticles (AuNPs) are used to deliver drugs and therapeutic
small molecule inhibitors to cancer cells. Evidence shows that AuNPs coated with nuclear …