We sought to determine the influence of sympathoexcitation on dynamic cerebral
autoregulation (CA), cerebrovascular reactivity, and ventilatory control in humans at high …

We hypothesized that 1) acute severe hypoxia, but not hyperoxia, at sea level would impair
dynamic cerebral autoregulation (CA); 2) impairment in CA at high altitude (HA) would be …

Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

Ventilation and cerebral blood flow (CBF) are both sensitive to hypoxia and hypercapnia. To
compare chemosensitivity in these two systems, we made simultaneous measurements of …

Cerebral blood flow (CBF) increases and dynamic cerebral autoregulation is impaired by
acute hypoxia. We hypothesized that progressive hypocapnia with restoration of arterial …

Abstract Ainslie, Philip N., and Andrew W. Subudhi. Invited Review: Cerebral blood flow at
high altitude. High Alt Med Biol. 15: 133–140, 2014.—This brief review traces the last 50 …

Acute exposure to hypoxia causes chemoreflex activation of the sympathetic nervous
system. During acclimatization to high altitude hypoxia, arterial oxygen content recovers, but …

The ventilatory response to hypoxia is complex. First contact with hypoxia causes an
increase in ventilation within seconds that reaches full intensity within minutes because of …

We tested the hypothesis that, following exposure to high altitude, cerebrovascular reactivity
to CO2 and cerebral autoregulation would be attenuated. Such alterations may predispose …

Controversy exists regarding the effect of high-altitude exposure on cerebrovascular CO2
reactivity (CVR). Confounding factors in previous studies include the use of different …