Oxytocin and cardioprotection in diabetes and obesity

M Jankowski, TL Broderick, J Gutkowska - BMC Endocrine Disorders, 2016 - Springer
Oxytocin (OT) emerges as a drug for the treatment of diabetes and obesity. The entire OT
system is synthesized in the rat and human heart. The direct myocardial infusion with OT into …

Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db/db mice

E Plante, A Menaouar, BA Danalache, D Yip… - …, 2015 - academic.oup.com
Oxytocin (OT) is involved in the regulation of energy metabolism and in the activation of
cardioprotective mechanisms. We evaluated whether chronic treatment with OT could …

Oxytocin revisited: its role in cardiovascular regulation

J Gutkowska, M Jankowski - Journal of neuroendocrinology, 2012 - Wiley Online Library
Traditionally associated with female reproduction, oxytocin (OT) was revisited recently and
was revealed to have several new roles in the cardiovascular system. Functional OT …

Preconditioning of stem cells by oxytocin to improve their therapeutic potential

N Noiseux, M Borie, A Desnoyers, A Menaouar… - …, 2012 - academic.oup.com
Principal limitation of cell therapy is cell loss after transplantation because of the interplay
between ischemia, inflammation, and apoptosis. We investigated the mechanism of …

Oxytocin: old hormone, new drug

J Gutkowska, M Jankowski - Pharmaceuticals, 2009 - mdpi.com
Oxytocin (OT), traditionally associated with reproductive functions, was revisited recently,
and several new functions in cardiovascular regulation were discovered. These functions …

[HTML][HTML] The role of oxytocin in cardiovascular protection

M Jankowski, TL Broderick, J Gutkowska - Frontiers in psychology, 2020 - frontiersin.org
The beneficial effects of oxytocin on infarct size and functional recovery of the ischemic
reperfused heart are well documented. The mechanisms for this cardioprotection are not …

[HTML][HTML] Oxytocin may have a therapeutical potential against cardiovascular disease. Possible pharmaceutical and behavioral approaches

B Buemann, K Uvnäs-Moberg - Medical hypotheses, 2020 - Elsevier
Based on the ancient role of oxytocin and its homologues as amplifiers of reproduction we
argue for an evolutionary coupling of oxytocin to signaling pathway which support …

Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion

A Gonzalez-Reyes, A Menaouar, D Yip… - Molecular and cellular …, 2015 - Elsevier
Oxytocin (OT) stimulates cardioprotection. Here we investigated heart-derived H9c2 cells in
simulated ischemia–reperfusion (I–R) experiments in order to examine the mechanism of OT …

Oxytocin increases glucose uptake in neonatal rat cardiomyocytes

M Florian, M Jankowski, J Gutkowska - Endocrinology, 2010 - academic.oup.com
We have recently shown that an entire oxytocin (OT) system, a peptide and its cognate
receptors, is synthesized in the heart. In fetal and newborn hearts, OT exists in its extended …

Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy

J Gutkowska, TL Broderick, D Bogdan… - The Journal of …, 2009 - Wiley Online Library
Regular physical activity is beneficial in preventing the risk of cardiovascular complications
of diabetes. Recent studies showed a cardioprotective role of oxytocin (OT) to induce …