Introduction Animal models play a crucial role in breast cancer research, in particular mice
and rats, who develop mammary tumors that closely resemble their human counterparts …

Research using animal model systems has been instrumental in delivering improved
therapies for breast cancer, as well as in generating new insights into the mechanisms that …

Since efficacy in one or more preclinical animal tumor models generally provides the
rationale in support of a new antineoplastic drug's probable benefit in humans, is the primary …

Breast cancer is one of the most common cancers worldwide, which makes it a very
impactful malignancy in the society. Breast cancers can be classified through different …

The intention of this review is to provide a succinct overview about the availability and
relevance of the major categories of mouse models for breast cancer. The review …

Survival rates of patients with early breast cancer in the United Kingdom and in the United
States have improved steadily over the past 15 years. The only way to continue or even …

Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive
molecular and cellular research, the mortality rate remains high. Preclinical testing of new …

Mammary cancer is one of the most common cancers, victimizing more than half a million of
women worldwide every year. Despite all the studies in this field, the current therapeutic …

Several animal models have been used to investigate the etiology and to understand the
mechanism of breast carcinogenesis. Advances in cancer management relied on the use of …

Introduction: Despite massive expenditures in research and development to cure breast
cancer, few agents that pass preclinical trials demonstrate efficacy in humans. Although this …