Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56

M Xue, K Zhang, K Mu, J Xu, H Yang, Y Liu, B Wang… - Oncogenesis, 2019 - nature.com
Breast cancer ranks no. 1 in women cancer worldwide, while 60–70% are estrogen receptor
alpha positive. The estrogen selective modulators, such as tamoxifen, become the effective …

[HTML][HTML] TRIM8 inhibits breast cancer proliferation by regulating estrogen signaling

Z Tian, J Tang, X Liao, Y Gong, Q Yang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Breast cancer (BC) is the most common female malignancy worldwide, and 70% of which
are estrogen receptor α (ERα) positive. Endocrine treatment, such as tamoxifen, is a primary …

[HTML][HTML] TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α

J Tang, Y Luo, Z Tian, X Liao, Q Cui, Q Yang, G Wu - Neoplasia, 2020 - Elsevier
Breast cancer is the most commonly diagnosed malignancy in female worldwide, over 70%
of which are estrogen receptor α (ERα) positive. ERα has a crucial role in the initiation and …

TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer

K Azuma, K Ikeda, T Suzuki, K Aogi… - Proceedings of the …, 2021 - National Acad Sciences
Increasing attention has been paid to roles of tripartite motif–containing (TRIM) family
proteins in cancer biology, often functioning as E3 ubiquitin ligases. In the present study, we …

Loss of TRIM31 promotes breast cancer progression through regulating K48-and K63-linked ubiquitination of p53

Y Guo, Q Li, G Zhao, J Zhang, H Yuan, T Feng… - Cell death & …, 2021 - nature.com
Breast cancer is the most common cancer in the world. Relapse and metastasis are
important factors endangering the life of breast cancer patients, but the mechanism is still …

TRIM59 overexpression correlates with poor prognosis and contributes to breast cancer progression through AKT signaling pathway

Y Liu, Y Dong, L Zhao, L Su, K Diao… - Molecular …, 2018 - Wiley Online Library
TRIM59 has been recently implicated in the carcinogenesis of several cancers such as lung
cancer, gastric cancer, and bladder cancer. However, its expression pattern and clinical …

TRIM27 functions as a novel oncogene in non-triple-negative breast cancer by blocking cellular senescence through p21 ubiquitination

L Xing, X Tang, K Wu, X Huang, Y Yi, J Huan - Molecular Therapy-Nucleic …, 2020 - cell.com
In the current study, we aimed to explore the correlation between TRIM27 and breast cancer
prognosis, as well as the functions of TRIM27 in breast cancer and their underlying …

[HTML][HTML] TRIM14 promotes breast cancer cell proliferation by inhibiting apoptosis

G Hu, W Pen, M Wang - Oncology Research, 2019 - ncbi.nlm.nih.gov
Abstract Tripartite motif-containing 14 (TRIM14) is abnormally expressed in several human
cancers. However, the function and expression of TRIM14 in human breast cancer are still …

[HTML][HTML] TRIM29 functions as a tumor suppressor in nontumorigenic breast cells and invasive ER+ breast cancer

J Liu, B Welm, KM Boucher, MTW Ebbert… - The American journal of …, 2012 - Elsevier
Tripartite motif–containing 29 (TRIM29) is a member of the TRIM protein family that has been
implicated in hematologic and solid tumor cancers. We found that TRIM29 functions as a …

Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer

W Zhou, Y Zhang, C Zhong, J Hu, H Hu… - Cancer management …, 2018 - Taylor & Francis
Background Tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin ligase, has been
implicated in autoimmune diseases. Dysregulation of TRIM21 contributes to the progression …