Objective—Cardiovascular diseases are associated with chronic activation of Rho-
associated kinases (ROCKs) and endothelial dysfunction. Both increased ROCK activity and …

Rho-associated kinases (ROCKs) have been shown to be involved in the pathogenesis of
atherosclerosis. Although smoking is associated with endothelial dysfunction and ROCK …

Endothelial dysfunction is a key event in the development of vascular disease, and it
precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase …

BACKGROUND: Rho-associated kinases (ROCKs) have been shown to be involved in the
pathogenesis of atherosclerosis. It is clinically important to estimate the degree of ROCK …

Cardiovascular diseases are associated with chronic activation of Rho-associated kinase.
Rho-associated kinase activity is significantly correlated with endothelial function and …

Background Recent evidence suggests that Rho‐kinase (ROCK) plays an important role in
the pathogenesis of atherosclerosis and a marker of atherosclerotic burden. Polyvascular …

Background The small GTPase RhoA (Ras homolog gene family, member A) regulates a
variety of cellular processes, including cell motility, proliferation, survival, and permeability …

Background Rho-associated kinases (ROCKs) play an important role in Ca 2+ sensitization
and vascular resistance. Activation of ROCKs is associated with hypertension. The purpose …

Atherosclerosis is a complex inflammatory process characterized by the cross-talk between
excessive inflammation and lipid accumulation. In the past few years, compelling evidence …

Rho-associated coiled-coil forming protein kinases (ROCKs), the downstream target
proteins of RhoA, are ubiquitously expressed serine-threonine protein kinases. ROCKs have …