BCL-XL, an anti-apoptotic BCL-2 family protein, plays a key role in cancer cell survival.
However, the potential of BCL-XL as an anti-cancer target has been hampered by the on …

Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and,
within tumors, their upregulation is common and promotes an immunosuppressive …

PROTACs are heterobifunctional small molecules that simultaneously bind a target protein
and a ubiquitin ligase, enabling ubiquitination and degradation of the target. Major progress …

Dear Editor, Targeted protein degradation (TPD) represents a promising research field that
has quickly attracted attention and efforts from both academia and pharmaceutical industry …

Proteins in the Bcl-2 family are central regulators of programmed cell death, and members
that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed in many cancers and …

Inhibition of anti-apoptotic BCL-2 (B-cell lymphoma 2) has recently emerged as a promising
new therapeutic strategy for the treatment of a variety of human cancers, including leukemia …

Overexpression of antiapoptotic members of the Bcl-2 family is observed in approximately
80% of B-cell lymphomas, contributing to intrinsic and acquired drug resistance. Nullifying …

The prosurvival BCL-2 family protein BCL-X L is often overexpressed in solid tumors and
renders malignant tumor cells resistant to anticancer therapeutics. Enhancing apoptotic …

BH3-only proteins trigger the stress apoptosis pathway and chemical mimetics have great
potential for cancer therapy. BH3-only proteins inhibit antiapoptotic members of the Bcl-2 …

B cell lymphoma 6 (BCL6), which encodes a transcriptional repressor, is a critical oncogene
in diffuse large B cell lymphomas (DLBCLs). Although a retro-inverted BCL6 peptide …