Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Osteoporosis is a complex multifactorial condition of the musculoskeletal system.
Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical …

Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are
important in determining peak bone mass and structure, as well as the predisposition to …

Epigenetic modification pertains to the alteration of genetic-expression, which could be
transferred to the next generations, without any alteration in the fundamental DNA …

The explosive growth in the field of molecular biology over the last two decades has started
to make a great impact on clinical medicine. Genes have been cloned for diseases that were …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are
embedded. Besides providing the internal support of the body and protection for vital …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Bone is an important tissue which is a structural body component, carrying out the roles of
mechanical stress response and organ/tissue protection. In addition, bone, as an integral …

Bone remodelling is an important process both throughout growth and in adult life. The
homeostasis of bone tissue is maintained by the balanced processes of bone resorption and …