Heart failure (HF) is a leading cause of morbidity and mortality in the United States and
worldwide. As a multifactorial syndrome with unpredictable clinical outcomes, identifying the …

Background: Limited knowledge exists of the extent of epigenetic alterations, such as DNA
methylation, in heart failure (HF). We conducted targeted DNA methylation sequencing to …

Ischemic cardiomyopathy (ICM) is the clinical endpoint of coronary heart disease and a
leading cause of heart failure. Despite growing demands to develop personalized …

Heart failure (HF) is a complex syndrome affecting millions of people around the world. Over
the past decade, the therapeutic potential of targeting epigenetic regulators in HF has been …

Epigenetic mechanisms such as microRNA and histone modification are crucially
responsible for dysregulated gene expression in heart failure. In contrast, the role of DNA …

Differential DNA methylation exists in the epigenome of end-stage failing human hearts but
whether it contributes to disease progression is presently unknown. Here, we report that …

Background: Biochemical DNA modification resembles a crucial regulatory layer among
genetic information, environmental factors, and the transcriptome. To identify epigenetic …

Aims Natriuretic peptides are useful for diagnosis and prognostication of heart failure of any
cause. Now, research aims to discover novel biomarkers that will more specifically define …

In this study, we investigated the role of DNA methylation [5-methylcytosine (5mC)] and 5-
hydroxymethylcytosine (5hmC), epigenetic modifications that regulate gene activity, in …

Heart failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide
morbidity. Despite its high prevalence, only half of patients with HF respond to guideline …