The mammalian ovarian follicle consists of a multilayered complex of somatic cells that
surround the oocyte. A signal from the follicle cells keeps the oocyte cell cycle arrested at …

Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding
somatic cells. Here we show that the orphan Gs-linked receptor GPR3, which is localized in …

Oocytes, the female germ cells, contain all the messenger RNAs necessary to start a new life
but typically wait until fertilization to begin development. The transition from oocyte to …

The arrest of meiotic prophase in mouse oocytes within antral follicles requires the G protein
Gs and an orphan member of the G protein–coupled receptor family, GPR3. To determine …

In mammalian oocytes, the maintenance of meiotic prophase I arrest prior to the surge of LH
that stimulates meiotic maturation depends on a high level of cAMP within the oocyte. In …

Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors
in the mural granulosa cells of the ovarian follicle. Prior work has established the central role …

The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers
that communicate signals from many hormones, neurotransmitters, chemokines, and …

Mammalian oocytes grow and undergo meiosis within ovarian follicles. Oocytes are arrested
at the first meiotic prophase, held in meiotic arrest by the surrounding follicle cells until a …

And so it is for the cell cycle. Most eukaryotic cells never re-duplicatetheir chromosomes
before sister chromatids have been segregated at the previous mitosis, never embark on …

The source of the inhibitory levels of cAMP that maintain oocytes meiotically arrested is
under controversy. A model for regulation of the meiotic division that suggests the transfer of …