A preliminary report: genistein attenuates cerebral ischemia injury in ovariectomized rats via regulation of the PI3K-Akt-mTOR pathway.
L Lu, Y Liu, Y Gong, X Zheng - General Physiology & …, 2019 - search.ebscohost.com
Stroke is a leading cause of disability and death in the worldwide. Therefore, prevention of
stroke is critically important. Genistein, a natural phytoestrogen extracted from soybeans …
stroke is critically important. Genistein, a natural phytoestrogen extracted from soybeans …
[HTML][HTML] Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of ERK activity in ovariectomized mice
S Wang, H Wei, M Cai, Y Lu, W Hou… - … journal of biological …, 2014 - ncbi.nlm.nih.gov
Stroke has severe consequences in postmenopausal women. As replacement therapy of
estrogen have various adverse effects and the undermined outcomes. Genistein, a natural …
estrogen have various adverse effects and the undermined outcomes. Genistein, a natural …
Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats
ZY Miao, X Xia, L Che, YT Song - Neurological Research, 2018 - Taylor & Francis
Objective: Postmenopausal women possess higher incidence of stroke and worse
prognosis. Although estrogen replacement therapy has obvious neuroprotective effects …
prognosis. Although estrogen replacement therapy has obvious neuroprotective effects …
Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-κB activation in a …
Recently, the treatment of stroke has focused on antioxidant therapies, where oxidative
stress is implicated. The preventive and therapeutic potential of plant compounds on …
stress is implicated. The preventive and therapeutic potential of plant compounds on …
Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation
Z Tian, C Tang, Z Wang - Journal of cellular biochemistry, 2019 - Wiley Online Library
Abstract Background Ginkgetin, extracted from Ginkgo biloba L leaves, has been
demonstrated to have potential anti‐inflammatory and immune‐suppressive properties. But …
demonstrated to have potential anti‐inflammatory and immune‐suppressive properties. But …
[HTML][HTML] Genistein-3′-sodium sulfonate ameliorates cerebral ischemia injuries by blocking neuroinflammation through the α7nAChR-JAK2/STAT3 signaling pathway …
J Xie, X Li, L Zhang, C Liu, JWH Leung, P Liu, Z Yu… - Phytomedicine, 2021 - Elsevier
Background Neuroinflammation plays a pivotal role in the acute progression of cerebral
ischemia/reperfusion injury (I/RI). We previously reported that genistein-3′-sodium …
ischemia/reperfusion injury (I/RI). We previously reported that genistein-3′-sodium …
Neuroprotective effects of genistein in mongolian gerbils: Estrogen receptor–β involvement
A Donzelli, D Braida, A Finardi, V Capurro… - Journal of …, 2010 - jstage.jst.go.jp
Genistein is a naturally occurring plant-derived phytoestrogen, present in the human diet,
known to possess some beneficial effects. The present study investigated the effect of …
known to possess some beneficial effects. The present study investigated the effect of …
Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus
HW Liang, SF Qiu, J Shen, LN Sun, JY Wang… - Neuroscience …, 2008 - Elsevier
Oxidative stress is believed to contribute to neuronal damage induced by cerebral
ischemia/reperfusion (I/R) injury. The present study was undertaken to evaluate the possible …
ischemia/reperfusion (I/R) injury. The present study was undertaken to evaluate the possible …
Genistein exerts neuroprotective effect on focal cerebral ischemia injury in rats
AB Aras, M Guven, T Akman, H Alacam, Y Kalkan… - Inflammation, 2015 - Springer
Brain ischemia and treatment are one of the important topics in neurological science. Free
oxygen radicals and inflammation formed after ischemia are accepted as the most important …
oxygen radicals and inflammation formed after ischemia are accepted as the most important …
Inhibition of DPP-4 activity and neuronal atrophy with genistein attenuates neurological deficits induced by transient global cerebral ischemia and reperfusion in …
Genistein, an isoflavonoid phytoestrogen, has been known for its potential pharmacological
properties especially for neuroprotection and treating diabetes. The present study aims to …
properties especially for neuroprotection and treating diabetes. The present study aims to …
相关搜索
- ovariectomized rats akt mtor
- ovariectomized rats ischemia injury
- ischemia injury akt mtor
- ovariectomized rats up regulation
- ovariectomized rats brain damage
- ovariectomized rats nrf2 expression
- neuronal damage rat hippocampus
- neuronal damage oxidative stress
- ischemia injury neuroprotective effect
- pathway activation neuroprotective effect
- apoptosis inhibition neuroprotective effect
- mongolian gerbils neuroprotective effects
- estrogen receptor neuroprotective effects
- signaling pathway ischemia injuries
- ovariectomized rats pi3k akt
- ischemia injury pi3k akt