Effective control of Epstein-Barr Virus–related hemophagocytic lymphohistiocytosis with immunochemotherapy

S Imashuku, S Hibi, T Ohara, A Iwai… - Blood, The Journal …, 1999 - ashpublications.org
The familial form of hemophagocytic lymphohistiocytosis (HLH) is a lethal disorder. Although
the prognosis for Epstein-Barr virus–associated HLH (EBV-HLH) remains uncertain …

Treatment of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH); update 2010

S Imashuku - Journal of pediatric hematology/oncology, 2011 - journals.lww.com
The clinical features of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-
HLH) vary significantly, from mild to severe, at the time of the treatment decision. There are …

Longitudinal follow-up of patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis

S Imashuku, T Teramura, H Tauchi, Y Ishida… - …, 2004 - haematologica.org
BACKGROUND AND OBJECTIVES: Although immunochemotherapy has been reported to
be an effective initial treatment for patients with Epstein-Barr virus-associated …

Treatment of Epstein‐Barr virus‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH) in young adults: A report from the HLH studyl center

S Imashuku, K Kuriyama, R Sakai… - Medical and …, 2003 - Wiley Online Library
Abstract Background Epstein‐Barr virus‐associated hemophagocytic lymphohistiocytosis
(EBV‐HLH), also known as EBV‐associated hemophagocytic syndrome, develops mostly in …

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults and adolescents—a life-threatening disease: analysis of 133 cases from a single center

W Lai, Y Wang, J Wang, L Wu, Z Jin, Z Wang - Hematology, 2018 - Taylor & Francis
ABSTRACT Objectives: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
is the most common type of infection-associated HLH. Previous studies were focused on …

Treatment strategies for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH)

S Imashuku, Y Tabata, T Teramura, S Hibi - Leukemia & lymphoma, 2000 - Taylor & Francis
In Epstein-Barr virus (EBV) infection, the virus immortalizes B lymphocytes and cytotoxic T
lymphocytes (CTLs) are directed toward both latent and lytic viral antigens expressed on …

Advances in the management of hemophagocytic lymphohistiocytosis.

S Imashuku - International journal of hematology, 2000 - europepmc.org
Hemophagocytic lymphohistiocytosis (HLH) is a prototype of the hemophagocytic syndrome
and occurs most often in children. Progress in cytokine research has now made it possible to …

Virus‐triggered secondary hemophagocytic lymphohistiocytosis

S Imashuku, A Morimoto, E Ishii - Acta Paediatrica, 2021 - Wiley Online Library
Primary (familial/hereditary) and secondary (non‐familial/hereditary) hemophagocytic
lymphohistiocytosis (HLH) are hyperinflammatory and hypercytokinemic syndromes …

Clinical features and treatment strategies of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis

S Imashuku - Critical reviews in oncology/hematology, 2002 - Elsevier
Epstein–Barr virus (EBV) is the major triggering factor producing hemophagocytic syndrome
or hemophagocytic lymphohistiocytosis (HLH). In this review, diagnostic problems, clinical …

Infection of T lymphocytes in Epstein‐Barr virus‐associated hemophagocytic lymphohistiocytosis in children of non‐Asian origin

K Beutel, U Gross‐Wieltsch, T Wiesel… - Pediatric blood & …, 2009 - Wiley Online Library
Abstract Background Epstein‐Barr virus (EBV) is one of the most frequent triggers of
hemophagocytic lymphohistiocytosis (HLH). EBV‐associated HLH (EBV‐HLH) and ectopic …